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Thornton Lab Publications

Book
     
Thornton JW. Pandora's Poison: Chlorine, Health, and a New Environmental Strategy. MIT Press, 2001.

Click on the book cover at right to read Terry Collins' review in Nature, or the icon at left to go to the publisher's site for the book.
 
Papers
Click on the PDF icon to download a reprint. Click on the icon at right to go to the paper at the journal's website.
This page is under construction: most of the PDF links are not yet available.
Kolcazkowski B, Thornton JW. A mixed model of heterotachy improves phylogenetic accuracy. Molecular Biology and Evolution (in press), 2008.
Ortlund EA, Bridgham JT, Redinbo MR, Thornton JW. Crystal structure of an ancient protein: evolution by conformational epistasis. Science 317:1544-1548, 2007.
Dean AM, Thornton JW. Mechanistic approaches to the study of evolution: the functional synthesis. Nature Reviews Genetics 8:675-688, 2007.
Kolaczkowski B, Thornton, JW. Effect of branch length uncertainty on posterior probabilities for phylogenetic hypotheses. Molecular Biology and Evolution 24:2108-2118, 2007.
Fox JE, Bridgham JT, Bovee TFH, Thornton JW. An evolvable oestrogen receptor activity sensor: development of a modular system for integrating multiple genes into the yeast genome. Yeast 24:379-390, 2007.
Kolaczkowski B, Thornton, JW. Is there a star-tree paradox? Molecular Biology and Evolution, 23:1819-1823, 2007.
Keay J, Bridgham JT, Thornton JW. The Octopus vulgaris estrogen receptor is a constitutive transcriptional activator: evolutionary and functional implications. Endocrinology 147:3861-3869, 2006.
Thornton JW, Bridgham JT. Using ancestral gene resurrection to understand the evolution of protein function. In: Liberles DA, ed. Ancestral Gene Reconstruction. Oxford University Press, in press, 2006.
Bridgham JB, Carroll SM. Thornton JW. Evolution of hormone-receptor complexity by Molecular Exploitation. Science 312:87-101, 2006. Supplementary info.
Thornton JW. Evolution of gene families. In: Evolutionary Genetics: Concepts and Case Studies, ed. C. Fox and J. Wolf. Oxford University Press, 2006.
Thornton JW, Kolaczkowski B. No magic pill for phylgoenetic error. Trends in Genetics 21:310-311, 2005.
Krylova IN, Sablin EP, Moore J, Xy RX, Waitt GM, Juzumiene D, Bynum JM, Montana V, Lebedeva L, McKay JA, Suzuwa M, Williams JD, Williams SP, Guy RK, Thornton JW, Fletterick RJ, Willson TM, Ingraham HA. Structural analyses of NR5 orphan receptors reveal a potential role as nuclear phosphatidyl inositol sensors. Cell 120:343-355, 2005.
Kolaczkowski B, Thornton JW. Performance of maximum parsimony and likelihood phylogenetics when evolution is heterogeneous. Nature 431:980-984, 2004.
Thornton JW. Resurrecting ancient genes: experimental analysis of extinct molecules. Nature Reviews Genetics 5:366-375, 2004.
Thornton JW, Need E, Crews D. Resurrecting the ancestral steroid receptor: ancient origin of estrogen signaling. Science 301:1714-1717, 2003.
Wilson VS, Cardon MC, Thornton JW, Korte JJ, Ankley GT, Welch J, Hartig PC. Cloning and in vitro expression and characterization of the androgen receptor and isolation of estrogen receptor from the fathead minnow (Pimephales promelas). Environmental Science and Technology 38:6314-21, 2004.
Wu KH, Tobias MT, Thornton JW, Kelley DB. Estrogen receptors in Xenopus: Duplicate genes, splice variants, and tissue-specific expression. General and Comparative Endocrinology 133:38-49, 2003.
Thornton JW. Nuclear receptor diversity: phylogeny, evolution and endocrine disruption. Pure and Applied Chemistry 75:1827-1839, 2003.
Thornton JW. A precautionary approach to assessing and managing endocrine disrupting chemicals. In: Science and the Precautionary Principle, ed. J. Tickner, Island Press, 2003.
Sarkar IN*, Thornton JW*, Planet PJ, Figurski D, Schierwater B, DeSalle R. An automated phylogenetic key for classifying homeoboxes. Molecular Phylogenetics and Evolution 24: 388-399, 2002 (* equal contributors).
Thornton JW, DeSalle R. Gene family phylogenetics: tracing protein evolution on trees. Experientia Supplementum (EXS) 92:191-207, 2002.
Thornton JW. Gene family phylogenetics: tracing protein evolution on trees. In: Techniques in Molecular Systematics, eds. DeSalle R, Giribet G, Wheeler W. Birkauser-Verlag, 2002.
Thornton JW, McCally M, Houlihan J. Biomonitoring of industrial pollutants: health and policy implications of the chemical body burden. Public Health Reports 117:315-23, 2002.
Thornton J, McCally M, Howard J. Body burdens of industrial chemicals in the general human population. In: Life Support: The Environment and Public Health ed. M. McCally, MIT Press, 2002.
Thornton JW. Evolution of vertebrate steroid receptors from an ancestral estrogen receptor by ligand exploitation and serial genome expansions. Proceedings of the National Academy of Sciences USA 98 (10), 5671-5676, 2001.
Thornton JW. Implementing green chemistry: an environmental policy for sustainability. Pure and Applied Chemistry 73:1231-1236, 2001.
Thornton JW, DeSalle R. A new test to localize and test the significance of incongruence: detecting domain shuffling in the nuclear receptor superfamily. Systematic Biology, 49:183-201, 2000.
Hawkins MB, Thornton JW, Crews D, Skipper JK, Dotte A, Thomas P. Identification of a third distinct estrogen receptor and reclassification of estrogen receptors in teleosts. Proceedings of the National Academy of Sciences USA, 97: 10751-10756, 2000.
Thornton JW, DeSalle R. Phylogenetics meets genomics: homology and evolution in gene families. Annual Review of Genomics and Human Genetics 1:43-72, 2000.
Thornton JW. Beyond risk: an ecological paradigm for persistent organic pollutants. International Journal of Occupational and Environmental Health 6:318-330, 2000.
Thornton JW, Kelley DB. Evolution of the androgen receptor: structure-function implications. BioEssays 20:820-829, 1998.
Thornton J, McCally M, Orris P, Weinberg J. Hospitals and plastics: dioxin prevention and medical waste incineration. Public Health Reports 111:298-313, 1996.