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Genetic mapping of stickleback phenotypic variation |
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| 1) Work on stickleback in the Cresko lab has led to the discovery that the developmental genetic basis of parallel bone evolution in these fish largely involves genes of major effect, most likely due to regulatory mutations in developmental genes. Surprisingly, the same genes and alleles have been implicated in populations that have independently evolved similar phenotypes. The Cresko lab is now in the process of understanding how these alleles effect their developmental changes, and how this genotype-to-phenotype mapping is affected by different environmental and population genetic contexts. |
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