Publications & Grants ___

Publications

2008
Phillips, P.C. 2008. Epistasis: the fundamental role of gene interactions in the structure and evolution of genetic systems. Nature Reviews Genetics, in press.
Kammenga, J.E., P.C. Phillips, M. de Bono, and A. Doroszuk. 2008. Beyond induced mutants: using worms to study natural variation in genetic pathways. Trends in Genetics 24:178-185.
Phillips, P. C. 2008. Evolutionary genetics: who shouldn't be your daddy. Nature 451:640-641.
Baltrus, D.A., K. Gullemin, and P.C. Phillips. 2008. Genetic exchange increases the rate of adaptation in the human pathogen Helicobacter pylori. Evolution 62:39-49.
2007
Phillips, P.C. 2007. What maintains genetic variation in natural populations? A commentary on the paper ‘The maintenance of genetic variability by mutation in polygenic characters with linked loci’ by Russell Lande. Genetical Research 89:385-386.
Anderson, J.L., L. Albergotti, S. Proulx, C. Peden, R.B. Huey, and P.C. Phillips. 2007. Thermal preference in Caenorhabditis elegans: a null model and empirical tests. Journal of Experimental Biology 210:3107-3116.
Maneol, D., S. Carvalho, P.C. Phillips, and H. Teotónio. 2007. Selection against males in Caenorhabditis elegans under two mutational treatments. Proceedings Royal Society of London B 274:417-424.
Cresko, W.A., K. McGuigan, P.C. Phillips, and J. Postlethwait. 2007. Developmental genetic basis of microevolution in threespine stickleback: progress and promise. Genetica 129:105-126.
2006
Estes, S., and P.C. Phillips. 2006. Variation in pleiotropy and the mutational underpinnings of the G matrix. Evolution 60:2655-60.
Janzen, F.H., and P.C. Phillips. 2006. Exploring the evolution of environmental sex determination. Journal of Evolutionary Biology 19:1775-1784.
Aagaard, J.E., J.H. Willis, and P.C. Phillips. 2006. Relaxed selection among duplicate floral regulatory gene in Lamiales. Journal of Molecular Evolution 63:493-503.
Teotónio, H., D. Maneol, and P.C. Phillips. 2006. Genetic variation for outcrossing among Caenorhabditis elegans isolates. Evolution 60:1300-1305.
Proulx, S., and P.C. Phillips. 2006. Allelic divergence precedes and promotes gene duplication. Evolution 60:881-892.
Phillips, P.C. 2006. One perfect worm. Trends in Genetics 22:405-407.
Kaplan, R.H., and P.C. Phillips. 2006. Ecological and developmental context of natural selection: Maternal effects and thermally induced plasticity in the frog Bombina orientalis. Evolution 60:142-156.
Phillips, P.C., and K.L. McGuigan. 2006. Evolution of genetic variance-covariance structure. In C. Fox and J. Wolf (eds.), Evolutionary Genetics: Concepts and Case Studies. Oxford University Press. Oxford, England.
2005
Aagaard, J.E., R.G. Olmstead, J.H. Willis, and P.C. Phillips. 2005. Duplication of floral regulatory genes in the Lamiales. American Journal of Botany 92:1284-1293.
Jovelin, R., and P.C. Phillips. 2005. Functional constraint and divergence in the G protein family of Caenorhabditis elegans and C. briggsae. Molecular Genetics and Genomics 273:299-310.
Ajie, B., S. Estes, M. Lynch, and P.C. Phillips. 2005. Behavioral degradation under mutation accumulation. Genetics 170:655-660.
Estes, S., B. Ajie, M. Lynch, and P.C. Phillips. 2005. Spontaneous mutational correlations for life-history, morphological, and behavioral characters in Caenorhabditis elegans. Genetics 170:645-653.
Kimmel, C.B., B. Ullmann, C. Walker, C. Wilson, M. Currey, P.C. Phillips, M.A. Bell, J.H. Poslethwait, and W.A. Cresko. 2005. Evolution and development of facial bone morphology in threespine stickleback. Proceedings of the National Academy of Science, USA 102:5791-6.
Proulx, S., D. Promislow, and P.C. Phillips. 2005. Network thinking in ecology and evolution. Trends in Ecology and Evolution 20:345-353.
Phillips, P.C. 2005. Testing hypotheses about the genetics of adaptation. Genetica 123:15-24. [Reprinted in Genetics of Adaptation, R. Mauricio (ed.), Springer, Dordrecht, The Netherlands (2005).]
Proulx, S., and P.C. Phillips. 2005. The opportunity for canalization and the evolution of genetic networks. American Naturalist 165:147-162.
2004
Aagaard, J.E., and P.C. Phillips. 2004. Accuracy and power of the likelihood ratio test for comparing evolutionary rates among genes. Journal of Molecular Evolution 60:426-433.
Estes, S., P.C. Phillips, D.R. Denver, W.K. Thomas, and M. Lynch. 2004. Mutation accumulation in populations of varying size: The distribution of mutational effects for fitness correlates in Caenorhabditis elegans. Genetics 166:1269-1279.
McGuigan, K., P.C. Phillips, J.H. Postlethwait. 2004. Evolution of sarcomeric myosin heavy chain genes: evidence from fish. Molecular Biology and Evolution 21:1042-1056.
Cresko, W.A., A. Amores, C. Wilson, J. Murphy, M. Currey, P. Phillips, M.A. Bell, C.B. Kimmel, and J.H. Postlethwait. 2004. Parallel genetic basis for repeated evolution of armor loss in Alaskan threespine stickleback populations. Proceedings of the National Academy of Science, USA 101:6050-6055.
Hersch, E., and P.C. Phillips. 2004. Power and potential bias in the detection of selection in natural populations. Evolution 58:479-8.
2003
Jovelin, R., B. Ajie, and P.C. Phillips. 2003. Molecular evolution and quantitative variation for chemosensory behavior in nematode genus Caenorhabditis. Molecular Ecology 12:1325-1337.
2002
Whitlock, M.C., P.C. Phillips, and K.A. Fowler. 2002. Changes in the genetic covariance matrix over twenty generations after a bottleneck. Evolution 56:1968-1975.
Steppan, S. J., P. C. Phillips, D. Houle. 2002. Comparative quantitative genetics: evolution of the G matrix. Trends in Ecology and Evolution 17:320-327.
Stewart, A.D., and P.C. Phillips. 2002. Selection and maintenance of androdioecy in Caenorhabditis elegans. Genetics 160:975-982.
2001
Phillips, P.C., M.C. Whitlock, and K.A. Fowler. 2001. Inbreeding changes the shape of the genetic covariance matrix in Drosophila melanogaster. Genetics 158:1137-1145.
2000
Whitlock, M.C., and P.C. Phillips. 2000. The exquisite corpse: a shifting view of the shifting balance. Trends in Ecology and Evolution 15:347-348.
Phillips, P.C., S. P. Otto, and M.C. Whitlock. 2000. Beyond the average: the evolutionary importance of gene interactions and variability of epistatic effects. Pages 20-38 in J. D. Wolf, E.D. Brodie, III, and M. J. Wade (eds.), Epistasis and the Evolutionary Process. Oxford University Press, Oxford, England.
1999
Phillips, P.C. and S.J. Arnold. 1999. Hierarchical comparison of genetic variance-covariance matrices. I. Using the Flury hierarchy. Evolution 53:1506-1515.
Arnold, S.J., and P.C. Phillips. 1999. Hierarchical comparison of genetic variance-covariance matrices. II. Coastal-inland divergence in the garter snake Thamnophis elegans. Evolution 53:1516-1527.
Whitlock, M.C., and P. C. Phillips. 1999. Genetic drift. Encyclopedia of Life Sciences. Nature Publishing Group, London. www.els.net
Phillips, P.C. 1999. From complex traits to complex alleles. Trends in Genetics 15:6-8.
1998
Phillips, P.C., and N.A. Johnson. 1998. The population genetics of synthetic lethals. Genetics 150:449-458.
Phillips, P.C. 1998. The language of gene interaction. Genetics 149:1167-1171.
Phillips, P.C. 1998. Genetic constraints at the metamorphic boundary: Morphological development in the wood frog, Rana sylvatica. Journal of Evolutionary Biology 11:453-463.
Phillips, P.C. 1998. Designing experiments to maximize the power of detecting correlations. Evolution 52:251-255.
<1997
Phillips, P.C. 1997. The rise and fall of new mutations. Trends in Ecology and Evolution 12:466-468.
Phillips, P.C. 1996. Waiting for a compensatory mutation: phase zero of the shifting-balance process. Genetical Research, Cambridge 67:271-283.
Phillips, P.C. 1996. Maintenance of polygenic variation via a migration-selection balance under uniform selection. Evolution 50:1334-1339.
Whitlock, M.C., P.C. Phillips, F.B.G Moore, and S. Tonsor. 1995. Epistasis and multiple fitness peaks. Annual Review of Ecology and Systematics 26:601-29.
Whitlock, M.C., P.C. Phillips, and M.J. Wade. 1993. Gene interaction affects the additive genetic variance in subdivided populations with migration and extinction. Evolution 47:1758-1769.
Phillips, P.C. 1993. Peak-shifts and polymorphism during phase three of Wright's shifting-balance process. Evolution 47:1733-1743.
Phillips, P.C., and M.J. Wade. 1990. Rana sylvatica (wood frog). Reproductive mortality. Herpetological Review 21:59.
Phillips, P.C., and S.J. Arnold. 1989. Visualizing multivariate selection. Evolution 43: 1209-1222.
Phillips, P.C., and R.H. Kaplan. 1987. A microscope-computer interface for the measurement of size and shape. Herpetologica 43: 384-385.

Grants

Current:
Natural variation in genomic targets of aging pathways (2008)
Ellison Medical Research Foundation
Partial selfing and the genetic basis of mating system variation (2007)
National Science Foundation (DEB-0641066)
Natural variation in aging: building upon the nematode model system (2007)
National Institutes of Health (R03AG029377)
OPUS: The evolution of genetic architecture (2006)
National Science Foundation (DEB-0614588)
Dissertation Research: Direct tests of the adaptive benefits of gene exchange in evolving bacterial populations (dissertation improvement grant for Richard Jovelin) (2007)
National Science Foundation (DEB-0710378)
Dissertation Research: Outcrossing in a self-Fertilizing species, adding the Caenorhabditis elegans tool-kit to the outcrossing-selfing paradigm (dissertation improvement grant for Levi Morran) (2007)
National Science Foundation (DEB-0710386)
The Microevolution of craniofacial development in threespine stickleback (2007)
National Science Foundation (IBN-0642264)
(with William Cresko [PI], John Postlethwait [co-PI] and Charles Kimmel [co-PI])
Integrated training in the evolution of development (2005)
National Science Foundation (DGE-0504627)
(with John Postlethwait [PI], Karen Guillemin [co-PI], and Rudy Raff [co-PI])
Prior:
Collaborative research: experimental tests of the adaptive significance of ectotherm thermoregulation (2004)
National Science Foundation (IBN-0416205)
Genetic basis of morphological evolution in stickleback (2003)
National Science Foundation (IBN-0236239)
(with John Postlethwait [PI] and Charles Kimmel [co-PI])
Mutation, mating systems, and the rate of adaptation (2003)
National Science Foundation (DEB-0236180)
Dissertation Research: Direct tests of the adaptive benefits of gene exchange in evolving bacterial populations (dissertation improvement grant for David Baltrus) (2005)
National Science Foundation (DEB-0508919)
(with Karen Guillemin [co-PI])
Robustness and genetic variation in gene networks (NRSA postdoctoral fellowship for Stephan Proulx) (2003)
National Institutes of Health (GM68382)
Dissertation Research: The evolution of floral developmental genes in Mimulus (dissertation improvement grant for Jan Aagaard) (2001)
National Science Foundation (DEB-0105176)
Evolution of genetic covariance structure (2001)
National Science Foundation (DEB-0088083)
A website providing research and education information in biology (2000)
National Science Foundation (DEB-9987394), February 2000 - March 2003
Quantitative trait loci for chemosensation (1998)
National Institutes of Health (GM54185), Janurary 1998 - December 2003
The evolution of virulence of equine infectious anemia virus: an experimental approach (1999)
National Institutes of Health (GM60751), October 1999 - September 2003 (with Susan Payne [PI] and Paul Chippindale [co-PI])
Dissertation Research: the Evolution of floral developmental genes in Mimulus (dissertation improvement grant with Jan Aagaard) (2001)
National Science Foundation (DEB-0105176)
Evolution of genetic covariance structure (2001)
National Science Foundation (DEB-0088083)
Resampling methods for quantitative genetic analysis (1997)
National Science Foundation (DBI-9722921), August 1997 - July 1999
Resampling methods for quantitative genetic analysis (1996)
National Science Foundation (BIR-9612469), August 1996 - July 1997
Mapping genes affecting complex traits (1995)
Research Enhancement Program, UTA
Real-time computing system for biological imaging and analysis (1993)
Harris Corporation
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